The tissue imaging system incorporates an integrated X-Ray -and Ultrasound Imaging system, The X~R,ay system is used for imaging and generating a 3D Volume of the extracted tissue sample (specimen). The Ultrasound Imaging system is used for imaging the body area of interest of the patient from which the tissue sample is to be extracted. On the display of the system, the physician, draws contours on the area of interest and the same is displayed as a 3D Volume. A 3D volume of the extracted tissue is generated using the x-ray imaging sub-system. Quantitative analysis is performed on the two 3D volumes (extracted tumor x-ray imaging and the contoured ultrasound imaging) to determine the difference between the contoured and the surgically extracted specimen to assist the physician in determining if further, surgical intervention is required.