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1. (WO2018200505) ERBB2/HER2 MUTATIONS IN THE TRANSMBRANE OR JUXTAMEMBRANE DOMAIN

Pub. No.:    WO/2018/200505    International Application No.:    PCT/US2018/029116
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: C12Q 1/6886
A61P 35/00
A61K 31/4709
A61K 31/517
A61K 39/395
C07K 16/32
Applicants: GENENTECH, INC.
F. HOFFMANN-LA ROCHE AG
Inventors: SESHAGIRI, Somasekar
Title: ERBB2/HER2 MUTATIONS IN THE TRANSMBRANE OR JUXTAMEMBRANE DOMAIN
Abstract:
The present disclosure relates to somatic ErbB2 mutations in cancer and provides methods of identifying, diagnosing, and prognosing ErbB2-positive cancers. The present disclosure further provides methods of treating cancer, including certain subpopulations of patients. The mutations are in the transmembrane domain or juxtamembrane domain of ErbB2.