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1. (WO2018200419) VIRAL VECTORS COMPRISING ENGINEERED AAV CAPSIDS AND COMPOSITIONS CONTAINING THE SAME

Pub. No.:    WO/2018/200419    International Application No.:    PCT/US2018/028954
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Apr 24 01:59:59 CEST 2018
IPC: C12N 1/15
C12N 1/19
C12N 1/21
C12N 15/09
C12N 5/10
C12N 15/86
C12N 15/861
C12N 15/864
A61K 35/76
A61K 35/761
A61K 38/16
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors: WILSON, James, M.
WANG, Qiang
Title: VIRAL VECTORS COMPRISING ENGINEERED AAV CAPSIDS AND COMPOSITIONS CONTAINING THE SAME
Abstract:
Provided herein is an artificial AAV capsid for delivery of an AAV vector genome carrying a transgene with an improved translatability among species. The artificial AAV capsid is also useful in generation of recombinant AAV comprising the same. Methods of increasing transduction of rAAV in a species and delivering therapeutic and other molecules thereto are also provided.