Search International and National Patent Collections

1. (WO2018200149) SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND PROTEIN KINASE INHIBITOR CHEMOTHERAPEUTICS

Pub. No.:    WO/2018/200149    International Application No.:    PCT/US2018/026231
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 06 01:59:59 CEST 2018
IPC: C12N 15/113
C12N 15/63
C07K 14/82
Applicants: JIVANA BIOTECNOLOGY INC.
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors: PRANHAKAR, Bellur
HOPPS, Sidney
MATHUR, Aditi
YUE, Fei
SAINI, Shikha
Title: SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND PROTEIN KINASE INHIBITOR CHEMOTHERAPEUTICS
Abstract:
The invention provides compositions and methods for treating cancers comprising administering a combination of antineoplastic agents, wherein the combination comprises protein kinase inhibitor chemotherapeutscs and one or more nucleic acid molecules capable of down-regulating expression of at least one splice variant of the IG20 gene, and wherein not all splice variants of the IG20 gene are down-regulated. In an embodiment, the splice variant of the IG20 gene is a MADD spiice variant and the nucleic acid molecules are siRNA, shRNA and antisense oligonucleotides which comprise a nucleic acid sequence complementary to a nucleic acid sequence of exon 13L of the MADD splice variant or to an mRNA transcript of exon 13L of the MADD splice variant. The invention encompasses methods of treating cancers which include combination therapy with nucleic acid molecules capable of down-regulating the expression of the at least one spiice variant of the IG20 gene, and protein kinase inhibitor chemotherapeutics.