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1. (WO2018200145) SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND NUCLEOSIDE ANALOG CHEMOTHERAPEUTICS

Pub. No.:    WO/2018/200145    International Application No.:    PCT/US2018/026177
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 06 01:59:59 CEST 2018
IPC: C07H 21/04
Applicants: JIVANA BIOTECHNOLOGY INC.
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors: HOPPS, Sidney
MATHUR, Aditi
PRABHAKAR, Bellur
YUE, Fei
SAINI, Shikha
Title: SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND NUCLEOSIDE ANALOG CHEMOTHERAPEUTICS
Abstract:
Compositions comprising a combination of antineoplastic agents, wherein the combination comprises nucleoside analog chemotherapeutics and one or more nucleic acid molecules capable of down-regulating expression of at least one splice variant of the IG20 gene, and wherein not all splice variants of the IG20 gene are down-regulated. The splice variant of the IG20 gene is at least a MADD splice variant and the nucleic acid molecules are siRNA, shRNA and/or antisense oligonucleotides which comprise a nucleic acid sequence complementary to a nucleic acid sequence of exon 13L of the MADD splice variant or to an mRNA transcript of exon 13L of the MADD splice variant. Methods of treating cancers by administering said compositions.