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1. (WO2018200144) SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND ANTHRACYCLINE CHEMOTHERAPEUTICS

Pub. No.:    WO/2018/200144    International Application No.:    PCT/US2018/026173
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 06 01:59:59 CEST 2018
IPC: C12N 15/113
C12N 15/06
A61P 31/00
C07H 21/02
A61K 31/7105
Applicants: JIVANA BIOTECHNOLOGY INC.
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors: PRABHAKAR, Bellur
HOPPS, Sidney
MATHUR, Aditi
YUE, Fei
SAINI, Shikha
Title: SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND ANTHRACYCLINE CHEMOTHERAPEUTICS
Abstract:
The invention provides compositions and methods for treating cancers comprising administering a combination of antineoplastic agents, wherein the combination comprises anthracycline chemotherapeutics and one or more nucleic acid molecules capable of down-regulating expression of at least one splice variant of the IG20 gene, and wherein not all splice variants of the IG20 gene are down-regulated. In an embodiment, the splice variant of the IG20 gene is a MADD spiice variant and the nucleic acid molecules are siRNA, shRNA and antisense oligonucleotides which comprise a nucleic acid sequence complementary to a nucleic acid sequence of exon 13L of the MADD splice variant or to an mRNA transcript of exon 13L of the MADD splice variant. The invention encompasses methods of treating cancers which include combination therapy with nucleic acid molecules capable of down-regulating the expression of the at least one splice variant of the IG20 gene, and anthracycline chemotherapeutics.