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1. (WO2018200040) COMPOSITIONS OF FIBROBLAST GROWTH FACTOR LIGANDS AND METHODS OF TREATING PATIENTS UNERGOING ISCHEMIA-REPERFUSION THERAPY
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Pub. No.: WO/2018/200040 International Application No.: PCT/US2018/000110
Publication Date: 01.11.2018 International Filing Date: 26.04.2018
IPC:
C07K 14/50 (2006.01) ,A61K 38/18 (2006.01) ,A61P 9/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
50
Fibroblast growth factor (FGF)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants:
UNIVERSITY OF CINCINNATI [US/US]; 51 Goodman Drive Suite 240 Cincinnati, OH 45221, US
Inventors:
SCHULTZ, Jo El J.; US
MOHAMMADI, Moosa; US
Agent:
EVERETT, Denise, M.; US
LORENTZ, Joshua, A.; US
LIVINGSTON, Jennifer, L.; US
OBERHAUS, Geoffrey, L.; US
NEAL, Cynthia, A.; US
Priority Data:
62/490,10326.04.2017US
Title (EN) COMPOSITIONS OF FIBROBLAST GROWTH FACTOR LIGANDS AND METHODS OF TREATING PATIENTS UNERGOING ISCHEMIA-REPERFUSION THERAPY
(FR) COMPOSITIONS DE LIGANDS DU FACTEUR DE CROISSANCE DES FIBROBLASTES ET MÉTHODES DE TRAITEMENT DE PATIENTS SUBISSANT UNE THÉRAPIE ISCHÉMIQUE DE REPERFUSION
Abstract:
(EN) Pharmaceutical compositions of native and engineered mutant Fibroblast Growth Factors (FGFs) and methods for treating patients undergoing ischemic cardiac reperfusion therapy to reduce or eliminate ischemic reperfusion injury, methods for treating patients suffering from or suspected of suffering from a myocardial infarction and about to undergo or undergoing cardiac reperfusion therapy to reduce extent of the myocardial infarction, and methods for treating patients who suffered a cardiac ischemic event to restore cardiac function to a pre-ischemic event level of cardiac function by administering a native or engineered mutant FGF, and, optionally, heparin.
(FR) L'invention concerne des compositions pharmaceutiques de facteurs de croissance des fibroblastes (FGF) natifs et modifiés ainsi que des méthodes de traitement de patients subissant une thérapie cardiaque d'ischémie-reperfusion pour réduire ou éliminer une lésion d'ischémie-reperfusion, des méthodes de traitement de patients souffrant ou suspectés de souffrir d'un infarctus du myocarde et sur le point de subir ou subissant une thérapie de reperfusion cardiaque pour réduire l'étendue de l'infarctus du myocarde, et des méthodes pour traiter des patients ayant souffert d'un événement ischémique cardiaque pour restaurer une fonction cardiaque à un niveau d'événement pré-ischémique de la fonction cardiaque par l'administration d'un FGF mutant natif ou modifié, et, éventuellement, de l'héparine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)