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1. (WO2018199797) SUBSTITUTED 2-METHYLIDENE-5-(PHENYLAMINO)-2,3-DIHYDROTHIOPHEN-3-ONES FOR TREATMENT OF LEUKEMIAS WITH TRANSLOCATIONS OF THE MLL GENE AND OTHER ONCOLOGICAL DISEASES

Pub. No.:    WO/2018/199797    International Application No.:    PCT/RU2017/000276
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 28 01:59:59 CEST 2017
IPC: C07D 333/36
C07D 409/06
C07D 409/12
C07D 409/14
C07D 413/14
A61K 31/4535
A61K 31/381
A61K 31/40
A61K 31/4155
A61K 31/4436
A61K 31/496
A61K 31/5377
A61P 35/00
Applicants: LIMITED LIABILITY COMPANY "ONCOTARTIS"
ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ОНКОТАРТИС"
Inventors: KAZYULKIN, Denis Nikolaevich
КАЗЮЛЬКИН, Денис Николаевич
KOROTCHKINA, Lioubov
КОРОЧКИНА, Любовь
Title: SUBSTITUTED 2-METHYLIDENE-5-(PHENYLAMINO)-2,3-DIHYDROTHIOPHEN-3-ONES FOR TREATMENT OF LEUKEMIAS WITH TRANSLOCATIONS OF THE MLL GENE AND OTHER ONCOLOGICAL DISEASES
Abstract:
The invention relates to the chemistry of organic compounds, pharmacology and medicine, and concerns the prevention and/or treatment of hyperproliferative diseases associated with the malignant transformation of cells expressing the enzyme carboxylesterase hCE1, and specifically, acute leukemias with translocations of the MLL gene, hepatocellular carcinomas, and pulmonary adenocarcinomas. For this purpose, compounds of general formula (I), general formula (II), or general formula (III) are proposed in which R1, R2, A, B, and Q have values indicated in the description. The invention also relates to pharmaceutical compositions containing the indicated compounds, as well as to the use of the above-mentioned compounds for the treatment and/or prevention of hyperproliferative diseases.