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1. (WO2018199775) ANALYTICAL AND THERAPEUTIC METHODS AND COMPOSITIONS, AND USES THEREOF

Pub. No.:    WO/2018/199775    International Application No.:    PCT/NZ2018/050057
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 27 01:59:59 CEST 2018
IPC: G01N 33/53
C07K 14/195
Applicants: AUCKLAND UNISERVICES
MORELAND, Nicole J
YOUNG, Paul Gary
PROFT, Thomas
Inventors: MORELAND, Nicole J
YOUNG, Paul Gary
PROFT, Thomas
Title: ANALYTICAL AND THERAPEUTIC METHODS AND COMPOSITIONS, AND USES THEREOF
Abstract:
The invention generally relates to compositions and methods for treating, detecting and assisting in the diagnosis of Streptococcus pyogenes infection, of rheumatic fever or of poststreptococcal glomerulonephritis (PSGN), and compositions and methods for assessing the propensity for developing rheumatic fever or PSGN in subjects in need thereof. Recombinant polypeptides, including recombinant Streptococcus pyogenes SpnA polypeptides, and compositions comprising such polypeptides, for use in such methods are also provided.