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1. (WO2018199710) FUSION PROTEIN COMPRISING PVR AND 4-1BBL AND USE THEREOF
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Pub. No.: WO/2018/199710 International Application No.: PCT/KR2018/005005
Publication Date: 01.11.2018 International Filing Date: 30.04.2018
IPC:
C07K 14/52 (2006.01) ,C07K 14/005 (2006.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
재단법인 목암생명과학연구소 MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH [KR/KR]; 경기도 용인시 기흥구 이현로 30번길 93 93, Ihyeon-ro 30beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do 16924, KR
Inventors:
이승훈 LEE, Seung-Hoon; KR
은소영 EUN, So-Young; KR
조의철 JO, Eui-Cheol; KR
권해냄 KWON, Hae-Naem; KR
김태윤 KIM, Taeyoon; KR
박혜영 PARK, Hye-Young; KR
오인재 OH, Injae; KR
남혜미 NAM, Hyemi; KR
원종화 WON, Jonghwa; KR
Agent:
제일특허법인 FIRSTLAW P.C.; 서울시 서초구 마방로 60 60 Mabang-Ro, Seocho-Ku, Seoul 06775, KR
Priority Data:
10-2017-005479828.04.2017KR
Title (EN) FUSION PROTEIN COMPRISING PVR AND 4-1BBL AND USE THEREOF
(FR) PROTÉINE DE FUSION COMPRENANT DU PVR ET DU 4-1BBL ET UTILISATION ASSOCIÉE
(KO) PVR 및 4-1BBL을 포함하는 융합단백질 및 이의 용도
Abstract:
(EN) The present invention relates to a fusion protein including PVR and 4-1BBL and a use thereof. Activating T cells to increase the secretion of TNF-α, IFN-γ, and Granzyme B, the fusion protein comprising PVR and 4-1BBL of the present invention can be effectively used as an immunopotentiator and an anticancer agent.
(FR) La présente invention concerne une protéine de fusion comprenant du PVR et du 4-1BBL et une utilisation associée. Grâce à l'activation des lymphocytes T afin d'augmenter la sécrétion du TNF-alpha, de l'IFN-gamma et de la Granzyme B, la protéine de fusion comprenant du PVR et du 4-1BBL de la présente invention peut s'utiliser efficacement comme immunopotentialisateur et comme agent anticancéreux.
(KO) 본 발명은 PVR 및 4-1BBL을 포함하는 융합단백질 및 이의 용도에 관한 것이다. 본 발명의 PVR 및 4-1BBL을 포함하는 융합단백질은 T세포를 활성화 시켜 TNF-α, IFN-γ 및 Granzyme B의 분비를 증가시키므로, 면역증강제 및 항암제로서 유용하게 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)