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1. (WO2018199698) COMPOSITION COMPRISING FIBROUS ACELLULAR DERMAL MATRIX AND BIOCOMPATIBLE POLYMER, AND METHOD FOR PRODUCING SAME

Pub. No.:    WO/2018/199698    International Application No.:    PCT/KR2018/004955
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: A61L 15/32
A61L 15/40
A61L 15/44
A61L 27/36
A61L 27/22
A61L 27/60
Applicants: CG BIO CO., LTD.
(주)시지바이오
Inventors: PARK, Heejun
박희준
RYU, Hyun-Seung
유현승
HAN, Jin-Wook
한진욱
LEE, Jihye
이지혜
JANG, Hak-Su
장학수
LEE, Sunny
이선이
Title: COMPOSITION COMPRISING FIBROUS ACELLULAR DERMAL MATRIX AND BIOCOMPATIBLE POLYMER, AND METHOD FOR PRODUCING SAME
Abstract:
The present invention relates to a composition comprising a human-derived acellular dermal matrix and gelatin. More specifically, the present invention relates to: a composition in which the degree of crosslinking, viscoelasticity, degree of cure and/or change in the extrusion load value of the composition of the fibrous acellular dermal matrix and the gelatin after sterilization is 30% or less, preferably 20% or less, most preferably 10% or less compared to the composition before sterilization; a method for producing the composition; and a sheet using the same. A wound dressing paste of the present invention is easily applicable to areas on which a conventional sheet-type acellular dermal matrix is difficult to apply, or to localized areas, is easy to use, being an out-of-the-box ready-to-use product, and is capable of quickly and fully curing even severe wounds without surgery. Also, the wound dressing paste is excellent in stably maintaining properties even in long-term or low-temperature storage, softly spreading and tightly adhering when applied to localized areas. Therefore, the wound dressing paste protects the wound area from external contaminants and maintains a moist environment, helping the wound area to be efficiently treated. In addition, a wound dressing sheet of the present invention has excellent bioadhesive properties and excellently retains shape during specialist procedures since the polymer structure hardly breaks down even during a long rehydration process. Also, the size of the wound dressing sheet can be adjusted as required in terms of length, width, and thickness for the wound area or specific features of surgery, thereby improving the quality of wound treatment.