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1. (WO2018199633) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AGING-RELATED DISEASES CONTAINING DECURSIN DERIVATIVE AS ACTIVE INGREDIENT
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Pub. No.: WO/2018/199633 International Application No.: PCT/KR2018/004812
Publication Date: 01.11.2018 International Filing Date: 25.04.2018
IPC:
C07D 493/04 (2006.01) ,A61K 31/37 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
366
having six-membered rings, e.g. delta-lactones
37
Coumarins, e.g. psoralen
Applicants:
(주)피알지에스앤텍 PRG S&TECH INC. [KR/KR]; 부산시 금정구 부산대학로63번길 2, 306호 (장전동, 부산대학교효원산학협동관) (Pusan National University Hyowon Industry-academic Cooperation Building, Jangjeon-dong), #306, 2, Busandaehak-ro 63beon-gil Geumjeong-gu Busan 46241, KR
Inventors:
박범준 PARK, Bum Joon; KR
송규용 SONG, Gyu Yong; KR
오유석 O, Yu Seok; KR
이지현 LEE, Jee Hyun; KR
윤은주 YUN, Eun Ju; KR
Agent:
특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM; 서울시 금천구 가산디지털1로151 이노플렉스1차 601호 #601 Innoplex 1 cha, 151Gasandigital 1-ro Geumcheon-gu Seoul 08506, KR
Priority Data:
10-2017-005278725.04.2017KR
10-2018-004559319.04.2018KR
Title (EN) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AGING-RELATED DISEASES CONTAINING DECURSIN DERIVATIVE AS ACTIVE INGREDIENT
(FR) COMPOSITION PHARMACEUTIQUE DESTINÉE À PRÉVENIR OU À TRAITER DES MALADIES LIÉES AU VIEILLISSEMENT, CONTENANT UN DÉRIVÉ DE DÉCURSINE COMME PRINCIPE ACTIF
(KO) 데커신 유도체를 유효성분으로 함유하는 노화 관련 질환 예방 또는 치료용 약학조성물
Abstract:
(EN) The present invention relates to a novel decursin derivative and a composition for preventing or treating aging-related diseases containing the same as an active ingredient. The novel decursin derivative has exhibited an excellent effect of inhibiting progerin expression and an excellent effect of inhibiting binding between progerin and lamin A, and it has been confirmed that the novel decursin derivative prolongs the survival period of animal models in which progeria is induced. Therefore, a compound of the present invention can be effectively used for the prevention or treatment of aging-related diseases such as progeria, etc.
(FR) La présente invention concerne un nouveau dérivé de décursine, ainsi qu'une composition destinée à la prévention ou au traitement de maladies liées au vieillissement, contenant ledit dérivé en tant que principe actif. Le nouveau dérivé de décursine a présenté un excellent effet d'inhibition de l'expression de la progérine et un excellent effet d'inhibition de la liaison entre la progérine et la lamine A, et il a été confirmé que le nouveau dérivé de décursine prolonge la période de survie de modèles animaux dans lesquels une progéria est induite. Par conséquent, un composé de la présente invention peut être utilisé efficacement dans la prévention ou le traitement de maladies liées au vieillissement telles que la progéria, etc.
(KO) 본 발명은 신규한 데커신 유도체 및 이를 유효성분으로 함유하는 노화 관련 질환 예방 또는 치료용 조성물에 관한 것으로, 상기 신규한 데커신 유도체는 우수한 프로게린 발현 억제 효과 및 프로게린 및 라민 A의 결합 억제 효과를 나타내었으며, 조로증이 유도된 동물 모델의 생존 기간을 연장시키는 것이 확인됨에 따라, 본 발명의 화합물은 조로증 등과 같은 노화관련 질환의 예방 또는 치료에 효과적으로 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)