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1. (WO2018199595) 4-1BBL MUTEIN AND FUSION PROTEIN COMPRISING SAME

Pub. No.:    WO/2018/199595    International Application No.:    PCT/KR2018/004745
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: C07K 14/52
C07K 14/54
A61K 38/00
Applicants: GENEXINE, INC.
주식회사 제넥신
Inventors: MOON, Jiwon
문지원
CHUNG, Eunju Esther
박은주
SHIN, Eun Ju
신은주
LIM, Hye Seong
임혜성
LEE, Hae Jun
이해준
Title: 4-1BBL MUTEIN AND FUSION PROTEIN COMPRISING SAME
Abstract:
The present invention relates to a novel 4-1BBL mutein and a fusion protein comprising the same. The 4-1BBL mutein of the present invention may form a structurally stable trimer. Therefore, the trimer of the 4-1BBL mutein can effectively bind to 4-1BB in an individual. In addition, when various active proteins are bound to the trimer of the 4-1BBL mutein, the trimer can be used as an anticancer composition and a composition for preventing or treating infectious diseases.