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1. (WO2018199562) 2-AMINO-2-(1-(2-(2-HYDROXYETHOXY)ETHYL)-1H-1,2,3-TRIAZOLE-4-YL)PROPANE-1,3-DIOL DERIVATIVE WHICH IS NOVEL COMPOUND, AND USE THEREOF
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Pub. No.: WO/2018/199562 International Application No.: PCT/KR2018/004641
Publication Date: 01.11.2018 International Filing Date: 20.04.2018
IPC:
C07D 249/04 (2006.01) ,A61K 31/4192 (2006.01) ,A23L 33/10 (2016.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
249
Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
04
1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4192
1,2,3-Triazoles
[IPC code unknown for A23L 33/10]
Applicants:
경북대학교 산학협력단 KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION [KR/KR]; 대구시 북구 대학로 80 (산격동, 경북대학교) (Kyungpook National University, Sangyeok-dong) 80, Daehak-ro, Buk-gu, Daegu 41566, KR
Inventors:
배재성 BAE, Jae-Sung; KR
진희경 JIN, Hee Kyung; KR
박민희 PARK, Min Hee; KR
Agent:
이희숙 LEE, Hee Sook; 서울시 강남구 테헤란로 33길 11, 9층 (역삼동, JS 빌딩) (JS building, Yeoksam-dong) 9th Fl, 11, Teheran-ro 33 gil Gangnam-gu Seoul 06141, KR
Priority Data:
10-2017-005549528.04.2017KR
Title (EN) 2-AMINO-2-(1-(2-(2-HYDROXYETHOXY)ETHYL)-1H-1,2,3-TRIAZOLE-4-YL)PROPANE-1,3-DIOL DERIVATIVE WHICH IS NOVEL COMPOUND, AND USE THEREOF
(FR) DÉRIVÉ 2-AMINO-2-(1-(2-(2-HYDROXYÉTHOXY)ÉTHYL)-1H-1,2,3-TRIAZOLE-4-YL)PROPANE-1,3-DIOL QUI EST UN NOUVEAU COMPOSÉ, ET SON UTILISATION
(KO) 신규 화합물 2-아미노-2-(1-(2-(2-히드록시에톡시)에틸)-1H-1,2,3-트리아졸- 4-일)프로판 -1,3-디올 유도체 및 이의 용도
Abstract:
(EN) The present invention relates to a 2-amino-2-(1-(2-(2-hydroxyethoxy)ethyl)-1H-1,2,3-triazole-4-yl)propane-1,3-diol derivative which is a novel compound represented by chemical formula 1, and a use thereof. The novel compound of chemical formula 1, of the present invention, has excellent ASM inhibitory effects and has a therapeutic effect on a decrease in Aβ plaques in Alzheimer's brain environment, improvement in memory and anxiety, alleviation of neurogenic inflammation, and the like, so as to be very useful in the development of an agent for preventing or treating degenerative neurological diseases including Alzheimer's disease, and depression, thereby having very excellent industrial applicability.
(FR) La présente invention concerne un dérivé 2-amino-2-(1-(2-(2-hydroxyéthoxy)éthyl)-1H-1,2,3-triazole-4-yl)propane-1,3-diol qui est un nouveau composé représenté par la formule chimique (1), et son utilisation. Le nouveau composé de formule chimique (1), de la présente invention, présente d’excellents effets d'inhibition de l’ASM et présente un effet thérapeutique sur une baisse des plaques d’Aβ dans l’environnement du cerveau Alzheimer, d’amélioration de la mémoire et de l’anxiété, de soulagement de l’inflammation neurogénique, et similaires, afin d’être très utile dans le développement d’un agent de prévention ou de traitement des maladies neurologiques dégénératives comprenant la maladie d’Alzheimer, et la dépression, ayant ainsi une applicabilité industrielle très bonne.
(KO) 본 발명은 화학식 1로 표시되는 신규 화합물 2-아미노 -2-(1-(2-(2-히드록시 에톡시)에틸) -1H-1,2,3-트리아졸 -4-일)프로판 -1,3-디올 유도체 및 이의 용도에 관 한 것이다. 본 발명의 화학식 1의 신규 화합물은 ASM 억제 효과가 탁월하고, 알츠 하이머 뇌환경에서 Αβ 플라크 감소, 기억력 및 불안증 개선, 신경염증 완화 등의 치료효과가 있어, 알츠하이머병을 포함하는 퇴행성 신경질환 및 우울증의 예방 또 는 치료제 개발에 매우 유용하게 사용될 수 있어 산업상 이용가능성이 매우 우수하 다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)