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1. (WO2018199538) FUSION PROTEIN, IN WHICH HAGFISH-DERIVED VLRB PROTEIN FROM WHICH HYDROPHOBIC TAIL DOMAIN HAS BEEN REMOVED AND C4BP OLIGOMERIZATION DOMAIN ARE BOUND, AND USE THEREOF

Pub. No.:    WO/2018/199538    International Application No.:    PCT/KR2018/004463
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 19 01:59:59 CEST 2018
IPC: C07K 14/725
C07K 14/47
C07K 16/46
G01N 33/53
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY
경상대학교산학협력단
IMMUCELL CO., LTD.
주식회사 이뮤셀
Inventors: JUNG, Tae Sung
정태성
KIM, Gyung Dong
김경동
IM, Se Pyung
임세평
LEE, Jung Suk
이정석
KIM, Young Rim
김영림
KIM, Jaesung
김재성
Title: FUSION PROTEIN, IN WHICH HAGFISH-DERIVED VLRB PROTEIN FROM WHICH HYDROPHOBIC TAIL DOMAIN HAS BEEN REMOVED AND C4BP OLIGOMERIZATION DOMAIN ARE BOUND, AND USE THEREOF
Abstract:
The present invention relates to a multivalent antibody having increased binding force to a target antigen and characterized in that a fusion protein, in which a hagfish-derived variable lymphocyte receptor B (VLRB) protein from which a hydrophobic tail domain is removed and a human-derived C4b-binding protein (C4bp) oligomerization domain are bound, is self-assembled and formed into a polymer.