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1. (WO2018199465) MOLECULAR BEACON-BASED OPTICAL GENETIC BIOSENSOR USING RETRO-REFLECTION PHENOMENON AND QUANTITATIVE ANALYSIS METHOD OF NUCLEIC ACID MOLECULE USING SAME

Pub. No.:    WO/2018/199465    International Application No.:    PCT/KR2018/002812
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Mar 10 00:59:59 CET 2018
IPC: C12Q 1/6818
G01N 21/17
G02B 5/12
Applicants: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
아주대학교산학협력단
Inventors: YOON, Hyun Chul
윤현철
KIM, Jae Ho
김재호
HAN, Yong Duk
한용덕
CHUN, Hyeong Jin
전형진
Title: MOLECULAR BEACON-BASED OPTICAL GENETIC BIOSENSOR USING RETRO-REFLECTION PHENOMENON AND QUANTITATIVE ANALYSIS METHOD OF NUCLEIC ACID MOLECULE USING SAME
Abstract:
An optical genetic biosensor is disclosed. The optical genetic biosensor comprises: a substrate; a molecular beacon unit fixed to the substrate and including an oligonucleotide binding selectively to a target nucleic acid molecule, and a first compound at the end of the oligonucleotide; an optical probing unit binding selectively to the first compound and capable of retro-reflecting irradiated light; a light source unit for irradiating light onto the optical probing unit; and a light reception unit for receiving the light retro-reflected by the optical probing unit. The optical genetic biosensor can allow the accurate quantitative analysis of target nucleic acid molecules for both non-spectral light sources and spectral light sources.