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1. (WO2018199408) OPHTHALMIC PHARMACEUTICAL COMPOSITION

Pub. No.:    WO/2018/199408    International Application No.:    PCT/KR2017/011293
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Oct 14 01:59:59 CEST 2017
IPC: A61K 38/17
A61K 9/00
A61K 47/02
A61K 47/30
Applicants: SAM CHUN DANG PHARM. CO., LTD.
Inventors: IM, Guang-Jin
HA, Byung-Jhip
PARK, Na-Won
PARK, Yong-Seop
Title: OPHTHALMIC PHARMACEUTICAL COMPOSITION
Abstract:
The present invention provides an ophthalmic pharmaceutical composition having a certain pH, comprising aflibercept as an active ingredient; an acetate salt buffering agent, wherein the ophthalmic pharmaceutical composition is free of an ionic tonicity agent. The ophthalmic pharmaceutical composition of the present invention can remarkably reduce the formation of dimeric and multimeric impurities and maintain the biological activity in a high level for a long time under the accelerated and stress conditions as well as under the cold storage condition.