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1. (WO2018199378) COMBINED IMMUNOSUPPRESSIVE METHOD OF ANTI-CD20 MONOCLONAL ANTIBODY AND TACROLIMUS IN CORNEAL XENOTRANSPLANTATION

Pub. No.:    WO/2018/199378    International Application No.:    PCT/KR2017/006091
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Jun 13 01:59:59 CEST 2017
IPC: A61K 39/395
A61K 31/436
A61K 31/56
A61K 31/573
C07K 16/28
Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
서울대학교 산학협력단
Inventors: KIM, Mee Kum
김미금
KIM, Jae Young
김재영
CHOI, Se Hyun
최세현
YOON, Chang Ho
윤창호
Title: COMBINED IMMUNOSUPPRESSIVE METHOD OF ANTI-CD20 MONOCLONAL ANTIBODY AND TACROLIMUS IN CORNEAL XENOTRANSPLANTATION
Abstract:
The present invention relates to a protocol for suppressing an immune rejection response that could occur at corneal xenotransplantation. The immune response suppressing method of the present invention can not only effectively suppress an immune rejection response attributed to a corneal graft in a recipient after penetrating corneal xenotransplantation, but also can stably maintain the engraftment of the corneal graft for a long period of time and allow the effective maintenance of indices such as a corneal thickness, an intraocular pressure, and the like, thus finding useful applications in corneal transplantation between difference species.