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1. (WO2018199340) OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF
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Pub. No.: WO/2018/199340 International Application No.: PCT/JP2018/017462
Publication Date: 01.11.2018 International Filing Date: 01.05.2018
IPC:
C12N 15/113 (2010.01) ,A61K 31/713 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
協和発酵キリン株式会社 KYOWA HAKKO KIRIN CO., LTD. [JP/JP]; 東京都千代田区大手町一丁目6番1号 1-6-1, Otemachi, Chiyoda-ku, Tokyo 1008185, JP
Inventors:
山本 潤一郎 YAMAMOTO, Junichiro; JP
篠原 史一 SHINOHARA, Fumikazu; JP
春元 俊正 HARUMOTO, Toshimasa; JP
本間 正一 HONMA, Masakazu; JP
萩原 健司 HAGIWARA, Kenji; JP
Agent:
稲葉 良幸 INABA, Yoshiyuki; JP
大貫 敏史 ONUKI, Toshifumi; JP
Priority Data:
2017-09061328.04.2017JP
Title (EN) OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF
(FR) DÉRIVÉ D’OLIGONUCLÉOTIDE OU SEL DE CELUI-CI
(JA) オリゴヌクレオチド誘導体またはその塩
Abstract:
(EN) The present invention provides: an oligonucleotide derivative or a salt thereof including a cyclic oligonucleotide and a linear oligonucleotide; and a method for manufacturing the same, wherein the cyclic oligonucleotide and the linear oligonucleotide have base sequences that are complementary to each other, and form a conjugate through hydrogen bonding of said complementary base sequences.
(FR) La présente invention concerne : un dérivé d'oligonucléotide ou un sel de celui-ci comprenant un oligonucléotide cyclique et un oligonucléotide linéaire ; et son procédé de production, où l'oligonucléotide cyclique et l'oligonucléotide linéaire ont des séquences de bases qui sont complémentaires l'une de l'autre, et forment un conjugué par liaisons hydrogène desdites séquences de bases complémentaires.
(JA) 本発明は、環状オリゴヌクレオチドと、線状オリゴヌクレオチドとを含むオリゴヌクレオチド誘導体またはその塩であって、環状オリゴヌクレオチドと、線状オリゴヌクレオチドとが互いに相補的な塩基配列を有し、該相補的な塩基配列の水素結合を介して環状オリゴヌクレオチドと、線状オリゴヌクレオチドとが複合体を形成している、オリゴヌクレオチド誘導体またはその塩等、およびその製造方法を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)