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1. (WO2018199338) NUCLEIC ACID MOLECULE FOR TREATMENT OF HEPATITIS B

Pub. No.:    WO/2018/199338    International Application No.:    PCT/JP2018/017347
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: C12N 15/113
A61K 9/02
A61K 9/06
A61K 9/08
A61K 9/10
A61K 9/14
A61K 9/20
A61K 9/48
A61K 9/70
A61K 9/72
A61K 31/7105
A61K 35/76
A61K 47/22
A61K 47/54
A61P 1/16
A61P 31/20
A61P 35/00
A61P 43/00
C12N 15/09
Applicants: HIROSHIMA UNIVERSITY
国立大学法人広島大学
SUMITOMO DAINIPPON PHARMA CO., LTD.
大日本住友製薬株式会社
BONAC CORPORATION
株式会社ボナック
Inventors: CHAYAMA, Kazuaki
茶山 一彰
YOSHIMA, Tadahiko
吉間 忠彦
MIZUTANI, Takayuki
水谷 隆之
Title: NUCLEIC ACID MOLECULE FOR TREATMENT OF HEPATITIS B
Abstract:
The present invention provides: a nucleic acid molecule that effectively inhibits hepatitis B virus gene expression; and a pharmaceutical composition that comprises said nucleic acid molecule and is used for inhibiting hepatitis B virus growth and for treating hepatitis B, hepatic cirrhosis, or hepatic cancer. More specifically, provided is a nucleic acid molecule that includes the nucleotide sequence defined in (i) or (ii) as a sequence for inhibiting the expression of hepatitis B virus gene. (i) Nucleotide sequence represented by SEQ ID NO:2; a nucleotide sequence represented by SEQ ID NO:2, wherein one or two bases are deleted, substituted, inserted, or added; or a nucleotide sequence that has 90% or more identity to the nucleotide sequence represented by SEQ ID NO:2. (ii) Nucleotide sequence represented by SEQ ID NO:1; a nucleotide sequence represented by SEQ ID NO:1, wherein one or two bases are deleted, substituted, inserted, or added; or a nucleotide sequence that has 90% or more identity to the nucleotide sequence represented by SEQ ID NO:1.