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1. (WO2018199337) COMPOUND HAVING SUBSTANCE THAT HAS AFFINITY FOR SOLUBLE PROTEIN, CLEAVABLE MOIETY, AND REACTIVE GROUP, OR SALT THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/199337 International Application No.: PCT/JP2018/017345
Publication Date: 01.11.2018 International Filing Date: 27.04.2018
IPC:
C07K 19/00 (2006.01) ,C07K 16/00 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
味の素株式会社 AJINOMOTO CO., INC. [JP/JP]; 東京都中央区京橋一丁目15番1号 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315, JP
Inventors:
山田 慧 YAMADA, Kei; JP
松田 豊 MATSUDA, Yutaka; JP
藤井 友博 FUJII, Tomohiro; JP
敷田 奈都紀 SHIKIDA, Natsuki; JP
湯地 玲子 YUJI, Reiko; JP
新保 和高 SHIMBO, Kazutaka; JP
伊東 祐二 ITO, Yuji; JP
Agent:
特許業務法人酒井国際特許事務所 SAKAI INTERNATIONAL PATENT OFFICE; 東京都千代田区霞が関3丁目8番1号 虎の門三井ビルディング Toranomon Mitsui Building, 8-1, Kasumigaseki 3-chome, Chiyoda-ku, Tokyo 1000013, JP
Priority Data:
2017-09067928.04.2017JP
Title (EN) COMPOUND HAVING SUBSTANCE THAT HAS AFFINITY FOR SOLUBLE PROTEIN, CLEAVABLE MOIETY, AND REACTIVE GROUP, OR SALT THEREOF
(FR) COMPOSÉ RENFERMANT UNE SUBSTANCE AYANT UNE AFFINITÉ POUR UNE PROTÉINE SOLUBLE, FRACTION CLIVABLE, ET GROUPE RÉACTIF, OU SEL DE CELUI-CI
(JA) 可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
Abstract:
(EN) The present invention provides a technique that enables modification of a soluble protein, particularly regioselective modification of a soluble protein. More specifically, the present invention provides a compound having a substance that has affinity for a soluble protein, a cleavable moiety, and a reactive group, the compound being represented by formula (I): A-L-B-R [in the formula, A is a substance that has affinity for a soluble protein, L is a cleavable linker that is a divalent group containing a cleavable moiety, B is (a) a divalent group containing a bioorthogonal functional group or (b) a divalent group not containing a bioorthogonal functional group, and R is a group that is reactive to the soluble protein], or a salt thereof.
(FR) La présente invention concerne une technique qui permet la modification d'une protéine soluble, en particulier la modification régiosélective d'une protéine soluble. Plus particulièrement, la présente invention concerne un composé renfermant une substance ayant une affinité pour une protéine soluble, une fraction clivable et un groupe réactif, le composé étant représenté par la formule (I) : A-L-B-R [dans la formule, A est une substance qui a une affinité pour une protéine soluble, L est un lieur clivable qui est un groupe divalent contenant une fraction clivable, B est (a) un groupe divalent contenant un groupe fonctionnel bioorthogonal ou (b) un groupe divalent ne contenant pas de groupe fonctionnel bioorthogonal, et R est un groupe qui est réactif vis-à-vis de la protéine soluble], ou un sel dudit composé.
(JA) 本発明は、可溶性タンパク質の修飾、特に、可溶性タンパク質の位置選択的な修飾を可能にする技術を提供する。より具体的には、本発明は、下記式(I): A-L-B-R (I) 〔式中、 Aは、可溶性タンパク質に対する親和性物質であり、 Lは、切断性部分を含む2価の基である切断性リンカーであり、 Bは、(a)生体直交性官能基を含む2価の基、または(b)生体直交性官能基を含まない2価の基であり、 Rは、前記可溶性タンパク質に対する反応性基である。〕で表される、可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)