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1. (WO2018199291) HETEROCYCLIC DERIVATIVE

Pub. No.:    WO/2018/199291    International Application No.:    PCT/JP2018/017204
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: C07F 5/02
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C07F 5/04
Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD.
大日本住友製薬株式会社
Inventors: KOIKE Sachiko
小池 祥子
TAKAI Kentaro
▲高▼井 健太郎
MIZUSHIMA Shingo
水嶋 真吾
KANAI Toshio
金井 利夫
Title: HETEROCYCLIC DERIVATIVE
Abstract:
The purpose of the present invention is to discover a novel compound having an excellent β-lactamase-inhibiting activity, and to provide a useful prophylactic or therapeutic agent for bacterial infectious diseases which comprises a combination of the compound with a β-lactam-type drug or the compound alone. A compound represented by formula (1a) or (1b) [in formulae (1a) and (1b), X represents an oxygen atom, a sulfur atom or -NRa1-, G represents a 4- to 20-membered nitrogenated non-aryl hetero ring which may be substituted, or a 5- or 6-membered nitrogenated heteroaryl group which may be substituted, and other groups are as defined in the description] or a pharmaceutically acceptable salt thereof.