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1. (WO2018199274) EXTRACORPOREAL ARTIFICIAL LIVER, DEVICE FOR EXTRACORPOREAL ARTIFICIAL LIVER OR HEPATOCYTE CULTURE
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Pub. No.: WO/2018/199274 International Application No.: PCT/JP2018/017122
Publication Date: 01.11.2018 International Filing Date: 27.04.2018
IPC:
A61M 1/36 (2006.01) ,C12M 1/12 (2006.01) ,C12M 3/00 (2006.01) ,C12N 5/0735 (2010.01) ,C12N 15/00 (2006.01) ,C12Q 1/68 (2018.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1
Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
12
with sterilisation, filtration, or dialysis means
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
073
Embryonic cells or tissues; Foetal cells or tissues
0735
Embryonic stem cells; Embryonic germ cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
米満 吉和 YONEMITSU Yoshikazu [JP/JP]; JP
株式会社ガイアバイオメディシン GAIA BIOMEDICINE INC. [JP/JP]; 福岡県福岡市中央区警固1-10-9-903 1-10-9-903, Kego, Chuo-ku, Fukuoka-shi, Fukuoka 8100023, JP
Inventors:
米満 吉和 YONEMITSU Yoshikazu; JP
原田 結 HARADA Yui; JP
Agent:
特許業務法人特許事務所サイクス SIKS & CO.; 東京都中央区京橋一丁目8番7号 京橋日殖ビル8階 8th Floor, Kyobashi-Nisshoku Bldg., 8-7, Kyobashi 1-chome, Chuo-ku, Tokyo 1040031, JP
Priority Data:
2017-09033528.04.2017JP
Title (EN) EXTRACORPOREAL ARTIFICIAL LIVER, DEVICE FOR EXTRACORPOREAL ARTIFICIAL LIVER OR HEPATOCYTE CULTURE
(FR) FOIE ARTIFICIEL EXTRACORPOREL, DISPOSITIF DE CULTURE DE FOIE ARTIFICIEL EXTRACORPOREL OU D'HÉPATOCYTE
(JA) 体外型の人工肝臓、及び体外型の人工肝臓用又は肝細胞培養用の器具
Abstract:
(EN) The present invention addresses the problem of providing an artificial liver using highly functional hepatocytes. Provided is an extracorporeal artificial liver comprising at least one module including: a plasma component inlet port and a plasma component outlet port; a plasma component circulation chamber having the plasma component inlet port and the plasma component outlet port; and a hepatocyte culture chamber in which hepatocytes having an ammonia metabolizing ability are cultured, and which is disposed adjacent to the plasma component circulation chamber and isolated from the plasma component circulation chamber by a separation membrane that permeates ammonia but does not permeate hepatocytes.
(FR) La présente invention aborde le problème de la fourniture d'un foie artificiel à l'aide d'hépatocytes hautement fonctionnels. L'invention concerne un foie artificiel extracorporel comprenant au moins un module comprenant : un orifice d'entrée de composant de plasma et un orifice de sortie de composant de plasma; une chambre de circulation de composant de plasma ayant l'orifice d'entrée de composant de plasma et l'orifice de sortie de composant de plasma; et une chambre de culture d'hépatocytes dans laquelle des hépatocytes ayant une capacité de métabolisation de l'ammoniac sont cultivés, et qui est disposée de façon adjacente à la chambre de circulation de composant de plasma et isolée de la chambre de circulation de composant de plasma par une membrane de séparation perméable à l'ammoniac et imperméable à l'hépatocytes.
(JA) 高機能肝細胞を用いた人工肝臓を提供することを課題とする。以下を含む少なくとも一個のモジュールを備える、体外型の人工肝臓を提供する: ・血漿成分入口ポート及び血漿成分出口ポート; ・血漿成分入口ポート及び血漿成分出口ポートを備える、血漿成分循環室;及び ・血漿成分循環室に隣接して配置され、血漿成分循環室とはアンモニアは透過するが肝細胞は透過しない分離膜で隔てられおり、アンモニア代謝能を有する肝細胞が培養されている肝細胞培養室。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)