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1. (WO2018199236) HETEROCYCLIC COMPOUND
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Pub. No.: WO/2018/199236 International Application No.: PCT/JP2018/016996
Publication Date: 01.11.2018 International Filing Date: 26.04.2018
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 9/04 (2006.01) ,A61P 9/12 (2006.01) ,A61P 11/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
04
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants:
武田薬品工業株式会社 TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 大阪府大阪市中央区道修町四丁目1番1号 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Inventors:
北村 周治 KITAMURA Shuji; JP
池田 善一 IKEDA Zenichi; JP
生駒 実 IKOMA Minoru; JP
渡部 浩史 WATANABE Koji; JP
廣瀬 英喜 HIROSE Hideki; JP
湯川 猛史 YUKAWA Takafumi; JP
森本 幸恵 MORIMOTO Sachie; JP
西澤 直城 NISHIZAWA Naoki; JP
浅見 泰司 ASAMI Taiji; JP
Agent:
大野 聖二 OHNO Seiji; JP
松任谷 優子 MATSUTOYA Yuko; JP
今野 智介 IMANO Tomoyuki; JP
Priority Data:
2017-08795027.04.2017JP
Title (EN) HETEROCYCLIC COMPOUND
(FR) COMPOSÉ HÉTÉROCYCLIQUE
(JA) 複素環化合物
Abstract:
(EN) Provided is a compound which has calcium-sensitive receptor antagonistic activity, and which may be expected to be useful as an agent for the prevention and/or treatment of cardiac failure, pulmonary hypertension and the like, or a salt of said compound. The compound represented by formula (I) or a salt of said compound has calcium-sensitive receptor antagonistic activity, and may be expected to be useful as an agent for the prevention and/or treatment of cardiac failure, pulmonary hypertension and the like. [In the formula, each of the symbols is as described in the description.]
(FR) L’invention concerne un composé présentant une activité antagoniste de récepteur sensible au calcium, et que l’on espère efficace pour le traitement ou la prévention de l’insuffisance cardiaque, de l’hypertension pulmonaire et similaire. L’invention concerne également un sel de ce composé. Plus spécifiquement, l’invention concerne un composé représenté par la formule générale (1) présentant une activité antagoniste de récepteur sensible au calcium, et que l’on espère efficace pour le traitement ou la prévention de l’insuffisance cardiaque, de l’hypertension pulmonaire et similaire. L’invention concerne également un sel de ce composé. [Dans la formule, chaque symbole est tel que défini dans la description.]
(JA) 本発明は、カルシウム感受性受容体拮抗作用を有し、心不全、肺高血圧症等の予防または治療剤として有用であると期待される化合物またはその塩を提供する。式(I)で表される化合物またはその塩は、カルシウム感受性受容体拮抗作用を有し、心不全、肺高血圧症等の予防または治療剤として有用であると期待される。 [式中、各記号は明細書記載のとおり]
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)