Search International and National Patent Collections

1. (WO2018199214) COAGULATION FACTOR IX WITH IMPROVED PHARMACOKINETICS

Pub. No.:    WO/2018/199214    International Application No.:    PCT/JP2018/016932
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 27 01:59:59 CEST 2018
IPC: C12N 15/12
A61K 38/36
A61K 39/395
A61K 47/68
A61P 7/04
C07K 14/745
C07K 16/36
C12N 15/13
C12P 21/02
Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA
中外製薬株式会社
Inventors: IGAWA, Tomoyuki
井川 智之
FUNAKI, Miho
舩木 美歩
MIYASHITA, Hiroyuki
宮下 紘幸
Title: COAGULATION FACTOR IX WITH IMPROVED PHARMACOKINETICS
Abstract:
The present invention provides a method for improving or controlling the plasma half-life and/or bioavailability of coagulation factor IX (FIX), the method being characterized by modifying the GLA domain. Examples of such modification include: (i) non-covalent bonding of a GLA-domain-recognizing antibody or an antibody fragment thereof to the GLA domain; (ii) a reduced number of Gla residues in the GLA domain compared to native FIX; (iii) deleting one or more glutamic acid group in the GLA domain and/or substituting the same with another amino acid; and (iv) deleting part or all of the GLA domain. The present invention also provides FIX with improved pharmacokinetics comprising such modifications, a pharmaceutical composition containing said FIX as an active ingredient, a method for producing said FIX, and so forth.