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1. (WO2018199166) NOVEL TETRAHYDRONAPHTHYL UREA DERIVATIVES

Pub. No.:    WO/2018/199166    International Application No.:    PCT/JP2018/016806
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 26 01:59:59 CEST 2018
IPC: C07D 213/75
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C07D 401/04
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C07D 417/04
Applicants: MOCHIDA PHARMACEUTICAL CO., LTD.
持田製薬株式会社
Inventors: SAITOH Fumihiko
斉藤 文彦
NAGASUE Hiroshi
永末 央
KAWADA Yuji
河田 裕治
SATOH Tsutomu
佐藤 勉
Title: NOVEL TETRAHYDRONAPHTHYL UREA DERIVATIVES
Abstract:
The purpose of the present invention is to provide: compounds having a TrkA inhibiting effect, or pharmacologically acceptable salts thereof, or solvates of these; pharmaceutical compositions characterized by containing these as an active ingredient; and the pharmaceutical application of these, especially agents for the prevention and/or treatment of diseases involving TrkA (such as pain, cancer, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infections, Sjogren's syndrome, endometriosis, kidney diseases, and osteoporosis). Specifically, provided are compounds represented by formula (I) or optical isomers thereof, or pharmacologically acceptable salts of these, or solvates of these, etc.