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|1. (WO2018199048) 5'-POSITION DIBENZYL MONOPHOSPHATE DERIVATIVE OF NUCLEOSIDE-BASED ANTICANCER AGENT OR ANTIVIRUS AGENT|
|Applicants:||OHARA PHARMACEUTICAL CO., LTD.
|Title:||5'-POSITION DIBENZYL MONOPHOSPHATE DERIVATIVE OF NUCLEOSIDE-BASED ANTICANCER AGENT OR ANTIVIRUS AGENT|
[Problem] To provide, in place of injected agents (nucleoside-based anticancer agents or antivirus agents) clinically used as therapeutic drugs for cancer or virus infections, a medicine that has high stability with respect to various hydrolytic metabolic enzymes, is absorbed into the body even by oral administration, and exhibits a cytocidal effect by being incorporated into a DNA and RNA biosynthetic route and inhibiting the modification and extension of DNA and RNA or inhibiting reverse transcriptases or inhibiting protein synthesis. [Solution] The aforementioned problem is solved by a novel compound represented by formula (I). (In the formula, D is the 5'-position moiety of a nucleoside-based anticancer agent or an antivirus agent, and R1 and R2 are each a benzyl group that may have the same substituent or different substituents.)