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1. (WO2018199048) 5'-POSITION DIBENZYL MONOPHOSPHATE DERIVATIVE OF NUCLEOSIDE-BASED ANTICANCER AGENT OR ANTIVIRUS AGENT

Pub. No.:    WO/2018/199048    International Application No.:    PCT/JP2018/016512
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: C07F 9/09
A61K 31/7068
A61P 31/12
A61P 35/00
C07H 19/04
C07H 19/10
C07H 19/20
Applicants: OHARA PHARMACEUTICAL CO., LTD.
大原薬品工業株式会社
Inventors: SAKO Magoichi
酒向 孫市
Title: 5'-POSITION DIBENZYL MONOPHOSPHATE DERIVATIVE OF NUCLEOSIDE-BASED ANTICANCER AGENT OR ANTIVIRUS AGENT
Abstract:
[Problem] To provide, in place of injected agents (nucleoside-based anticancer agents or antivirus agents) clinically used as therapeutic drugs for cancer or virus infections, a medicine that has high stability with respect to various hydrolytic metabolic enzymes, is absorbed into the body even by oral administration, and exhibits a cytocidal effect by being incorporated into a DNA and RNA biosynthetic route and inhibiting the modification and extension of DNA and RNA or inhibiting reverse transcriptases or inhibiting protein synthesis. [Solution] The aforementioned problem is solved by a novel compound represented by formula (I). (In the formula, D is the 5'-position moiety of a nucleoside-based anticancer agent or an antivirus agent, and R1 and R2 are each a benzyl group that may have the same substituent or different substituents.)