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1. (WO2018199015) TRANSDERMALLY ABSORBABLE PREPARATION AND METHOD FOR PRODUCING SAME

Pub. No.:    WO/2018/199015    International Application No.:    PCT/JP2018/016441
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Apr 24 01:59:59 CEST 2018
IPC: A61K 31/381
A61K 9/70
A61K 47/10
A61K 47/32
A61K 47/34
A61P 25/14
A61P 25/16
A61P 43/00
Applicants: NIPRO CORPORATION
ニプロ株式会社
Inventors: FUKETA, Hiroshi
更田 宏史
SAWADA, Hidenori
澤田 英範
KAWAMURA, Naohisa
川村 尚久
Title: TRANSDERMALLY ABSORBABLE PREPARATION AND METHOD FOR PRODUCING SAME
Abstract:
This transdermally absorbable preparation is provided with a support, a reservoir layer containing rotigotine or a salt thereof, an adhesive layer containing a rubber-based adhesive, and a release liner, in the stated order. While having skin permeability equivalent to that of commercial transdermally absorbable preparations containing rotigotine, the present invention makes it possible to, e.g., provide higher adhesiveness than in these preparations and/or maintain the stability of the rotigotine or salt thereof without containing sulfite. This makes it possible in this transdermally absorbable preparation to prevent detachment from the skin of a patient and/or prevent induction of skin hypersensitivity in the patient, and to properly administer rotigotine or a salt thereof to the patient.