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|1. (WO2018198842) THERAPEUTIC AGENT FOR NONALCOHOLIC FATTY LIVER DISEASE|
|Applicants:||KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
|Title:||THERAPEUTIC AGENT FOR NONALCOHOLIC FATTY LIVER DISEASE|
Provided is a prophylactic/therapeutic drug capable of improving fatty liver (NAFL) and early nonalcoholic steatohepatitis (NASH) from among the nonalcoholic fatty liver diseases (NAFLD) for which no effective treatment method is widely available at present. The present invention primarily has an aldehyde oxidase inhibitor as an active ingredient, and secondarily has an aldehyde oxidase inhibitor and nicotinic acid and/or a nicotinic acid derivative as active ingredients, thereby making it possible to effectively prevent/treat and improve nonalcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH) caused by a metabolic pathway in which nicotinamide N1-methyl transferase (NNMT) and aldehyde oxidase function (fig. 3).