Search International and National Patent Collections

1. (WO2018198842) THERAPEUTIC AGENT FOR NONALCOHOLIC FATTY LIVER DISEASE

Pub. No.:    WO/2018/198842    International Application No.:    PCT/JP2018/015629
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sun Apr 15 01:59:59 CEST 2018
IPC: A61K 45/00
A61K 31/455
A61K 31/502
A61P 1/16
A61P 43/00
Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
国立大学法人九州大学
Inventors: ISHII Yuji
石井 祐次
TAKEUCHI Kenji
竹内 健二
Title: THERAPEUTIC AGENT FOR NONALCOHOLIC FATTY LIVER DISEASE
Abstract:
Provided is a prophylactic/therapeutic drug capable of improving fatty liver (NAFL) and early nonalcoholic steatohepatitis (NASH) from among the nonalcoholic fatty liver diseases (NAFLD) for which no effective treatment method is widely available at present. The present invention primarily has an aldehyde oxidase inhibitor as an active ingredient, and secondarily has an aldehyde oxidase inhibitor and nicotinic acid and/or a nicotinic acid derivative as active ingredients, thereby making it possible to effectively prevent/treat and improve nonalcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH) caused by a metabolic pathway in which nicotinamide N1-methyl transferase (NNMT) and aldehyde oxidase function (fig. 3).