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|1. (WO2018198030) METHOD FOR MODULATING PHAGOCYTIC UPTAKE OF AN ACTIVE INGREDIENT OR A PRECURSOR THEREOF BY MACROPHAGES|
|Applicants:||UNIVERSITÀ DEGLI STUDI DI FERRARA
UNIVERSITÀ DEGLI STUDI DI MODENA E REGGIO EMILIA
LEO, Eliana Grazia
|Title:||METHOD FOR MODULATING PHAGOCYTIC UPTAKE OF AN ACTIVE INGREDIENT OR A PRECURSOR THEREOF BY MACROPHAGES|
The present invention relates to a method for modulating phagocytic uptake of a water-insoluble active ingredient or a water-insoluble precursor thereof, by macrophages, involving the use of nanoparticles of the active ingredient or of the precursor thereof coated with at least one bile acid or a salt thereof, in order to selectively direct said active ingredient, once it is in circulation, towards the target site of interest. The invention further relates to the use of said nanoparticles in the treatment or diagnosis of a disease affecting the macrophages or of a solid tumor.