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1. (WO2018198030) METHOD FOR MODULATING PHAGOCYTIC UPTAKE OF AN ACTIVE INGREDIENT OR A PRECURSOR THEREOF BY MACROPHAGES

Pub. No.:    WO/2018/198030    International Application No.:    PCT/IB2018/052849
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: A61K 9/14
A61K 9/51
A61K 47/54
Applicants: UNIVERSITÀ DEGLI STUDI DI FERRARA
UNIVERSITÀ DEGLI STUDI DI MODENA E REGGIO EMILIA
Inventors: DALPIAZ, Alessandro
PAVAN, Barbara
FOGAGNOLO, Marco
PAGANETTO, Guglielmo
LEO, Eliana Grazia
IANNUCCELLI, Valentina
MARETTI, Eleonora
Title: METHOD FOR MODULATING PHAGOCYTIC UPTAKE OF AN ACTIVE INGREDIENT OR A PRECURSOR THEREOF BY MACROPHAGES
Abstract:
The present invention relates to a method for modulating phagocytic uptake of a water-insoluble active ingredient or a water-insoluble precursor thereof, by macrophages, involving the use of nanoparticles of the active ingredient or of the precursor thereof coated with at least one bile acid or a salt thereof, in order to selectively direct said active ingredient, once it is in circulation, towards the target site of interest. The invention further relates to the use of said nanoparticles in the treatment or diagnosis of a disease affecting the macrophages or of a solid tumor.