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1. (WO2018197997) METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS

Pub. No.:    WO/2018/197997    International Application No.:    PCT/IB2018/052710
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 20 01:59:59 CEST 2018
IPC: A61K 31/4192
A61K 31/454
A61K 31/496
A61K 31/5377
A61P 35/00
Applicants: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Inventors: NELLORE, Kavitha
HOSAHALLI, Subramanya
Title: METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS
Abstract:
The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R1, R2 and R3 which have the meanings given in the specification, and pharmaceutically acceptable salts thereof.