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1. (WO2018197874) CLOSTRIDIUM DIFFICILE BIOMARKERS AND USES THEREOF

Pub. No.:    WO/2018/197874    International Application No.:    PCT/GB2018/051090
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 26 01:59:59 CEST 2018
IPC: G01N 33/569
Applicants: THE UNIVERSITY OF NOTTINGHAM
Inventors: MONAGHAN, Dr Tanya M.
NEGM, Dr Ola H.
Title: CLOSTRIDIUM DIFFICILE BIOMARKERS AND USES THEREOF
Abstract:
The present invention provides a method of determining the severity of a Clostridium difficile infection in a subject, the method comprising the steps of: (i) obtaining a sample from a subject having or suspected of having Clostridium difficile infection; (ii) detecting one or more biomarkers in the sample, wherein the one or more biomarkers are selected from the group consisting of antibodies to the Clostridium difficile toxin A or a fragment thereof, antibodies to the Clostridium difficile toxin B or a fragment thereof, antibodies to a Clostridium difficile surface layer protein or a fragment thereof, and IFNγ; and (iii) determining, from the results in (ii), whether the subject has a mild Clostridium difficile infection or a severe Clostridium difficile infection.