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1. (WO2018197868) HEMATOPOIETIC STEM CELL EXPANSION METHOD
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Pub. No.: WO/2018/197868 International Application No.: PCT/GB2018/051082
Publication Date: 01.11.2018 International Filing Date: 25.04.2018
IPC:
C12N 5/0789 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0789
Stem cells; Multipotent progenitor cells
Applicants:
PLASTICELL LIMITED [GB/GB]; 5 New Street Square London EC4A 3TW, GB
Inventors:
HERNANDEZ, Diana; GB
Agent:
GILL JENNINGS & EVERY LLP; The Broadgate Tower 20 Primrose Street London EC2A 2ES, GB
STEVENS, Fiona; GB
Priority Data:
1706544.225.04.2017GB
Title (EN) HEMATOPOIETIC STEM CELL EXPANSION METHOD
(FR) PROCÉDÉ D'EXPANSION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES
Abstract:
(EN) A method to expand hematopoietic stem and progenitor cells (HSPC) wherein the method comprises obtaining an isolated population of HSPC the culturing the isolated population of HSPC in the presence of a histone deacetylase inhibitor (HDAC inhibitor), to form a cultured population, then adding an aminothiol compound to the cultured population.
(FR) L'invention concerne un procédé d'expansion de cellules souches et progénitrices hématopoïétiques (HSPC), le procédé comprenant l'obtention d'une population isolée de HSPC, la culture de la population isolée de HSPC en présence d'un inhibiteur d'histone désacétylase (inhibiteur de HDAC) pour former une population de culture, puis l'ajout d'un composé aminothiol à la population de culture.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)