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1. (WO2018197655) PROCESS FOR OBTAINING OMPHALOTIN IN A HOST CELL COMPRISING POLYNUCLEOTIDES ENCODING FOR POLYPEPTIDES INVOLVED IN THE OMPHATOLIN BIOSYNTHESIS
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Pub. No.: WO/2018/197655 International Application No.: PCT/EP2018/060835
Publication Date: 01.11.2018 International Filing Date: 27.04.2018
IPC:
C12N 9/02 (2006.01) ,C12N 9/10 (2006.01) ,C12N 9/58 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
58
derived from fungi
Applicants:
TECHNISCHE UNIVERSITÄT BERLIN [DE/DE]; Straße des 17. Juni 135 10623 Berlin, DE
Inventors:
RAMM, Sascha; DE
MÜHLENWEG, Agnes; DE
POCH-HASNEK, Annette; DE
MÖSKER, Eva; DE
SÜSSMUTH, Roderich; DE
KRAWCZYK, Bartlomiej; DE
Agent:
MORAWSKI, Birgit; MAIKOWSKI & NINNEMANN PATENTANWÄLTE PARTNERSCHAFT MBB 15 09 20 10671 Berlin, DE
Priority Data:
17168405.327.04.2017EP
Title (EN) PROCESS FOR OBTAINING OMPHALOTIN IN A HOST CELL COMPRISING POLYNUCLEOTIDES ENCODING FOR POLYPEPTIDES INVOLVED IN THE OMPHATOLIN BIOSYNTHESIS
(FR) PROCÉDÉ D'OBTENTION D'OMPHALOTINE DANS UNE CELLULE HÔTE COMPRENANT DES POLYNUCLÉOTIDES CODANT POUR DES POLYPEPTIDES IMPLIQUÉS DANS LA BIOSYNTHÈSE DE L'OMPHALOTINE
Abstract:
(EN) The present invention refers to a host cell for the heterologous synthesis of at least one omphatolin compound comprising comprising polynucleotides encoding for polypeptides involved in the omphatolin biosynthesis, an expression vector comprising said polynucleotides and a process for obtaining at least one omphalotin compound from said host cell.
(FR) La présente invention concerne une cellule hôte pour la synthèse hétérologue d'au moins un composé d'omphalotine comprenant des polynucléotides codant pour des polypeptides impliqués dans la biosynthèse de l'omphalotine, un vecteur d'expression comprenant lesdits polynucléotides et un procédé d'obtention d'au moins un composé omphalotine à partir de ladite cellule hôte.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)