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1. (WO2018197638) NOVEL USE OF (5R)-5-[5-[{2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-METHYLPROPANOYL}(METHYL)AMINO]-4-(4-FLUORO-2-METHYLPHENYL)-2-PYRIDINYL]-2-METHYL-D-PROLINAMIDE
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Pub. No.: WO/2018/197638 International Application No.: PCT/EP2018/060791
Publication Date: 01.11.2018 International Filing Date: 26.04.2018
IPC:
A61K 31/44 (2006.01) ,A61P 11/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
14
Antitussive agents
Applicants:
NERRE THERAPEUTICS LIMITED [GB/GB]; Stevenage Bioscience Catalyst, Office F25 Incubator Building, Gunnels Wood Road, Stevenage Herts SG1 2FX, GB
Inventors:
TROWER, Mike; GB
Agent:
MURGITROYD & COMPANY; Scotland House 165-169 Scotland Street Glasgow Strathclyde G5 8PL, GB
Priority Data:
62/491,12627.04.2017US
Title (EN) NOVEL USE OF (5R)-5-[5-[{2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-METHYLPROPANOYL}(METHYL)AMINO]-4-(4-FLUORO-2-METHYLPHENYL)-2-PYRIDINYL]-2-METHYL-D-PROLINAMIDE
(FR) NOUVELLE UTILISATION DU (5R)-5-[5-[{2-[3,5-BIS(TRIFLUOROMÉTHYL)PHÉNYL]-2-MÉTHYLPROPANOYL}(MÉTHYL)AMINO]-4-(4-FLUORO-2-MÉTHYLPHÉNYL)-2-PYRIDINYL]-2-MÉTHYL-D-PROLINAMIDE
Abstract:
(EN) Use of the compound (5R)-5-[5-[{2-[3, 5-bis (trifluoromethyl) phenyl]-2-methylpropanoyl} (methyl) amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D- prolinamide or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing it for the treatment of chronic cough and to combinations for such a use.
(FR) La présente invention concerne l'utilisation du composé (5R)-5-[5-[{2-[3,5-bis(trifluorométhyl)phényl]-2-méthylpropanoyl}(méthyl)amino]-4-(4-fluoro-2-méthylphényl)-2-pyridinyl]-2-méthyl-D- prolinamide ou des sels pharmaceutiquement acceptables de celui-ci et des compositions pharmaceutiques le contenant dans le traitement de la toux chronique et des combinaisons destinées à une telle utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)