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1. (WO2018197633) DIAGNOSTIC TOOL TO DETERMINE PODOCYTE FOOT PROCESS EFFACEMENT

Pub. No.:    WO/2018/197633    International Application No.:    PCT/EP2018/060779
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 27 01:59:59 CEST 2018
IPC: G01N 33/68
Applicants: ERNST-MORITZ-ARNDT-UNIVERSITÄT GREIFSWALD
Inventors: ENDLICH, Karlhans
ENDLICH, Nicole
SIEGERIST, Florian
Title: DIAGNOSTIC TOOL TO DETERMINE PODOCYTE FOOT PROCESS EFFACEMENT
Abstract:
The present invention relates to a method for diagnosing or pre-diagnosing a disease associated with podocyte foot process effacement in a subject or for determining the risk of a subject to develop a disease associated with podocyte foot process effacement, said method comprising the steps of a) determining the length of the slit diaphragm (ISD) formed by podocyte foot processes in a specific area A in a renal tissue sample of said subject by super resolution light microscopy; b) comparing the length of the slit diaphragm (ISD) formed by podocyte foot processes in a specific area A as determined in step (a) with the length of the slit diaphragm (ISD) formed by podocyte foot processes in a comparable specific area A in a renal tissue sample of a subject who at the time of the sampling showed no clinical symptoms of a disease associated with podocyte foot process effacement, wherein a deviation indicates a disease associated with podocyte foot process effacement.