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1. (WO2018197583) USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH P21 ACTIVATORS IN THE TREATMENT OF CANCER

Pub. No.:    WO/2018/197583    International Application No.:    PCT/EP2018/060637
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 26 01:59:59 CEST 2018
IPC: A61K 31/549
A61K 31/4045
A61P 35/00
Applicants: ISTITUTO EUROPEO DI ONCOLOGIA
UNIVERSITÀ DEGLI STUDI DI MILANO
Inventors: MINUCCI, Saverio
PELICCI, Pier Giuseppe
HOSSEINI, Seyed Amir
Title: USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH P21 ACTIVATORS IN THE TREATMENT OF CANCER
Abstract:
The present disclosure relates to methods of treating cancer and pharmaceutical compositions for use in the treatment of cancer, including LSD1-inhibitor-resistant cancers, comprising administering to a subject an effective amount of a cell cycle inhibitor, such as a CDK4/6 inhibitor or a p21 enhancer, and an effective amount of a LSD1 inhibitor.