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1. (WO2018197547) METHODS OF TREATING DISEASES RELATED TO NET FORMATION WITH PARENTERAL ADMINISTRATION OF POLYSIALYLATED DNASE I

Pub. No.:    WO/2018/197547    International Application No.:    PCT/EP2018/060565
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 26 01:59:59 CEST 2018
IPC: A61K 47/61
A61P 25/28
Applicants: LIPOXEN TECHNOLOGIES LIMITED
Inventors: GENKIN, Dmitry
Title: METHODS OF TREATING DISEASES RELATED TO NET FORMATION WITH PARENTERAL ADMINISTRATION OF POLYSIALYLATED DNASE I
Abstract:
The present invention provides conjugates of deoxyribonuclease enzymes with water soluble polymers such as PSA having improved pharmacokinetic attributes. These modifications provide unexpectedly high levels of DNA hydrolytic activity in blood and other bodily tissues over the time due to markedly increased distribution phase and reduced clearance of DNase conjugates after delivery to blood circulation relative to the unconjugated compounds, while half-life and residence time of conjugates remains almost unchanged compared to the unconjugated DNase compounds. The compositions of the invention are used for parenteral treatment of diseases related to NET formation and the presence of extracellular DNA.