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1. (WO2018197544) BI- OR MULTI-DIFFERENTIATED ORGANOID
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Pub. No.: WO/2018/197544 International Application No.: PCT/EP2018/060559
Publication Date: 01.11.2018 International Filing Date: 25.04.2018
IPC:
C12N 5/071 (2010.01) ,C12N 5/079 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
079
Neural cells
Applicants:
IMBA - INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH [AT/AT]; Dr.Bohrgasse 3 1030 Vienna, AT
Inventors:
KNOBLICH, Jürgen; AT
BAGLEY, Joshua A.; AT
Agent:
SONN & PARTNER PATENTANWÄLTE; Riemergasse 14 1010 Vienna, AT
Priority Data:
17168051.525.04.2017EP
Title (EN) BI- OR MULTI-DIFFERENTIATED ORGANOID
(FR) ORGANOÏDE BI-OU MULTI-DIFFÉRENCIÉ
Abstract:
(EN) The present invention relates to an in vitro method of producing a bi- or multi-differentiated tissue with at least two tissue types comprising the steps of developing a first tissue to a stage of differentiation of interest, developing a second tissue to a stage of differentiation of interest differing from the stage of differentiation of interest of the first tissue, placing said first and second tissue in a vicinity sufficient for fusion by growth, allowing the first and second tissue to grow and fuse to each other, thereby producing a bi- or multi- differentiated tissue comprising the first and second tissue with different stages of differentiation; bi- or multi- differentiated tissue obtained by such a method; uses of the tissue and kits for performing the method.
(FR) La présente invention concerne une méthode de production in vitro d'un tissu bi-ou multi-différencié avec au moins deux types de tissu comprenant les étapes consistant à développer un premier tissu à un stade de différenciation d'intérêt, développer un second tissu à une étape de différenciation d'intérêt différente de l'étape de différenciation d'intérêt du premier tissu, placer lesdits premier et second tissus dans un voisinage suffisant pour la fusion par croissance, permettre aux premier et second tissus de croître et de fusionner l'un avec l'autre, ce qui permet de produire un tissu bi-ou multi-différencié comprenant les premier et second tissus avec différents stades de différenciation ; un tissu bi-ou multi-différencié obtenu par une telle méthode ; des utilisations du tissu et des kits pour mettre en oeuvre la méthode.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)