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1. (WO2018197520) METHODS AND COMPOSITIONS OF ANTI-CRISPR PROTEINS FOR USE IN PLANTS

Pub. No.:    WO/2018/197520    International Application No.:    PCT/EP2018/060510
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: C07K 14/005
C07K 14/315
C12N 5/10
C12N 15/63
Applicants: DUPONT NUTRITION BIOSCIENCES APS
UNIVERSITÉ LAVAL (CANADA)
Inventors: FREMAUX, Christophe
HORVATH, Philippe
ROMERO, Dennis A
HYNES, Alexander
MOINEAU, Sylvain
ROUSSEAU, Geneviève
YOUNG, Joshua
LEMAY, Marie-Laurence
Title: METHODS AND COMPOSITIONS OF ANTI-CRISPR PROTEINS FOR USE IN PLANTS
Abstract:
Methods and compositions are provided for the use of anti-CRISPR (ACR) proteins in plants, including modulation of Cas endonuclease activity, improvement of frequency of homologous recombination, control of Cas endonuclease activity during various cell cycles, spatial and/or temporal regulation of Cas endonuclease activity in plants, usage in gene activation or repression, as well as reduction of off-target polynucleotide cleavage.