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1. (WO2018197475) PROCESSES FOR THE PREPARATION OF FURAZANOBENZIMIDAZOLES AND CRYSTALLINE FORMS THEREOF

Pub. No.:    WO/2018/197475    International Application No.:    PCT/EP2018/060454
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: C07D 413/04
C07C 229/26
A61K 31/4245
A61P 35/00
Applicants: BASILEA PHARMACEUTICA INTERNATIONAL AG
Inventors: WELTI, Gregor
HEUBES, Markus
TAGLIAFERRI, David
Title: PROCESSES FOR THE PREPARATION OF FURAZANOBENZIMIDAZOLES AND CRYSTALLINE FORMS THEREOF
Abstract:
The present invention provides processes for preparing a compound of formula (I) and pharmaceutically acceptable salts thereof, comprising deprotecting a compound of formula (II), wherein each R3 independently represents a tertiary alkyl group, preferably wherein each R3 is tertiary butyl. The invention also provides intermediates useful for preparing compounds of formula (I) and processes for preparing these intermediates. Additionally the invention provides polymorphic forms of the dichloride salt of the compound of formula (I) and their use in the treatment of proliferative disorders.