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1. (WO2018197408) SOLUBLE AND IMMUNOREACTIVE ZIKA VIRUS NS1 POLYPEPTIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/197408 International Application No.: PCT/EP2018/060333
Publication Date: 01.11.2018 International Filing Date: 23.04.2018
IPC:
C07K 14/18 (2006.01) ,G01N 33/569 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
18
Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Straße 116 68305 Mannheim, DE (DE)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
ROCHE DIAGNOSTICS OPERATIONS, INC. [US/US]; 9115 Hague Road Indianapolis, Indiana 46250-0457, US (US)
Inventors:
FAATZ, Elke; DE
GLOECK, Mario; DE
MUENCH, Peter; DE
RIEDEL, Alexander; DE
SCHOLZ, Christian; DE
TABARES, Gloria; DE
Agent:
SCHWARZ, Ralf; DE
IMMENDOERFER-RUEHLE, Ulrike; DE
KNAUER, Martin; DE
LOHE, Hans-Joerg; DE
MUSSAUER, Heiko; DE
RAUSCHER, Andreas; DE
VON CAMPENHAUSEN, Harald; DE
HOEVELMANN, Sascha; DE
RIWOTZKI, Karsten; DE
KUNSTMANN, Tobias; DE
RITTER, Claudia; DE
MEINEL, Anne Julia; DE
MOLNAR, Ferenc; DE
Priority Data:
17168197.626.04.2017EP
Title (EN) SOLUBLE AND IMMUNOREACTIVE ZIKA VIRUS NS1 POLYPEPTIDES
(FR) POLYPEPTIDES NS1 DE VIRUS ZIKA SOLUBLES ET IMMUNORÉACTIFS
Abstract:
(EN) The invention concerns a polypeptide suitable for detecting antibodies against Zika virus in an isolated biological sample comprising a Zika virus NS1 wing domain specific amino acid sequence and variants thereof, wherein no further Zika virus specific amino acid sequences are present in said polypeptide. This polypeptide does not immunologically cross-react with antibodies raised against structurally related antigens from tick-borne encephalitis virus, Dengue virus 1-4, West Nile virus, yellow fever virus or Japanese encephalitis virus, but immunologically reacts with antibodies raised against full length Zika virus NS1 antigen. Also disclosed is a method of producing a soluble and immunoreactive Zika virus NS1 polypeptide as well as methods and kits for detecting antibodies specific for Zika virus in an isolated sample.
(FR) L'invention concerne un polypeptide approprié pour la détection d'anticorps contre le virus Zika dans un échantillon biologique isolé comprenant une séquence d'acides aminés spécifique au domaine wing NS1 du virus Zika et des variants de celle-ci, aucune autre séquence d'acides aminés spécifiques du virus Zika n'étant présente dans ledit polypeptide. Le polypeptide de l'invention ne présente pas de réaction immunologique croisée avec les anticorps dirigés contre les antigènes structurellement apparentés du virus de l'encéphalite transmis par les tiques, le virus 1-4 de la Dengue, le virus du Nil occidental, le virus de la fièvre jaune ou le virus de l'encéphalite japonaise, mais réagit immunologiquement avec des anticorps dirigés contre l'antigène NS1 du virus Zika pleine longueur. L'invention concerne également un procédé de production d'un polypeptide NS1 du virus Zika soluble et immunoréactif ainsi que des procédés et des kits pour détecter des anticorps spécifiques du virus Zika dans un échantillon isolé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)