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1. (WO2018197394) USE OF WITHANIA SOMNIFERA EXTRACT TO PROTECT AGAINST AIR POLLUTION RELATED DISEASES

Pub. No.:    WO/2018/197394    International Application No.:    PCT/EP2018/060301
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Apr 24 01:59:59 CEST 2018
IPC: A61K 36/81
A61K 31/58
A61K 45/06
A61P 39/00
Applicants: DSM IP ASSETS B.V.
Inventors: BENDIK, Igor
BOEHLENDORF, Bettina
HUG, Hubert, Paul
MUSSLER, Bernd
RICHARD, Nathalie
Title: USE OF WITHANIA SOMNIFERA EXTRACT TO PROTECT AGAINST AIR POLLUTION RELATED DISEASES
Abstract:
The present invention relates to systemic detoxification by using extracts of Withania somnifera (ashwagandha) and its Nrf2-activating components withaferin-A, 12- deoxywithastramonolide, and Quresimine A. When ingested, the transcription factor Nrf2, which is a crucial element in intracellular detoxification pathways, leads to elimination of potentially toxic compounds. In parallel, the expression of inflammatory cytokines is decreased. Therefore, the extract can be used to reduce the adverse effects of air pollution generally (and especially of particulate air pollution), which includes: cardiovascular problems, respiratory diseases, and chronic inflammation of tissues that come into contact with air borne particles.