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1. (WO2018197374) COMPRESSION AND ANNOTATION OF DIGITAL WAVEFORMS FROM SERIAL READ NEXT GENERATION SEQUENCING TO SUPPORT REMOTE COMPUTING BASE CALLING

Pub. No.:    WO/2018/197374    International Application No.:    PCT/EP2018/060263
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Apr 24 01:59:59 CEST 2018
IPC: G06F 19/28
Applicants: KONINKLIJKE PHILIPS N.V.
Inventors: GROSS, Brian, David
Title: COMPRESSION AND ANNOTATION OF DIGITAL WAVEFORMS FROM SERIAL READ NEXT GENERATION SEQUENCING TO SUPPORT REMOTE COMPUTING BASE CALLING
Abstract:
A method (100) for processing sequencing data, including: (i) generating (120), by a sequencing platform, a plurality of sequencing signals from a sequencing operation, each of the plurality of sequencing signals representing a genetic sequence; (ii) sampling (130), by a controller, each of the plurality of sequencing signals at a Nyquist rate of the sequencing platform to generate an upsampled signal; (iii) receiving (140), for each of the plurality of sequencing signals, the respective upsampled signal and information associated with the respective sequencing signal, comprising a base pair read number and a time stamp for the respective sequencing signal; (iv) packaging (150), by the controller for each sequencing signal, the received upsampled signal, base pair read number, and time stamp into a data packet; (v) organizing (160) the packaged data packets into a multiplexed single data stream; and (vi) transmitting (170) the multiplexed single data stream to a remote system.