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1. (WO2018197296) PROCESS FOR THE PREPARATION OF DES-A-STEROIDS, INTERMEDIATES USEFUL FOR THE SYNTHESIS OF 9BETA,10ALFA-STEROIDS

Pub. No.:    WO/2018/197296    International Application No.:    PCT/EP2018/059890
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 19 01:59:59 CEST 2018
IPC: C07J 1/00
Applicants: NEWCHEM S.P.A.
Inventors: LOPOPOLO, Gianfranco
FABRIS, Francesco
MONTORSI, Mauro
MERLO, Massimo
GAMBARIN, Luca
DI BRISCO, Roberto
ZAUPA, Giovanni
GENONI, Andrea
ANDRIOLO, Erika
Title: PROCESS FOR THE PREPARATION OF DES-A-STEROIDS, INTERMEDIATES USEFUL FOR THE SYNTHESIS OF 9BETA,10ALFA-STEROIDS
Abstract:
The present invention relates to a process for the synthesis of intermediates of general formula (I): by means of a simultaneous protection and hydrogenation reaction of an intermediate of formula (II), according to the scheme below: Compounds (I) are intermediates useful for the preparation of steroidal compounds with a (9β,10α) configuration, which are an important group of molecules with known pharmacological activity.