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1. (WO2018197193) OPTICAL SCANNING ARRANGEMENT AND METHOD

Pub. No.:    WO/2018/197193    International Application No.:    PCT/EP2018/059005
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Apr 10 01:59:59 CEST 2018
IPC: G02B 21/24
G02B 21/36
Applicants: EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG
Inventors: FEIRER, Christian
BERNITT, Erik
PAUL, Marc
ROZNOWICZ, Rafael
Title: OPTICAL SCANNING ARRANGEMENT AND METHOD
Abstract:
It is provided a method for optical scanning of at least one object region (105) placed on a transparent specimen holder (107), the method comprising: for each sample lateral position (x1) of plural predefined sample lateral positions (x0, x1, x2) performing a focus determination by: performing laser reflection and using a first camera (109) taking plural first images to determine a reference distance (rd) between the specimen holder (107) and an objective lens (113); performing transmission flash illumination and using a second camera (111) taking plural second images to define a focus distance taking into account the reference distance (rd); after completing the focus determination, determining a focus distance topology (600, 700) across the object region (105) based on the focus distances determined for all sample lateral positions (x0, x1, x2); and laterally moving the specimen holder (107) and acquiring third images while focusing according to the focus distance topology (600, 700).