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1. (WO2018196883) METHOD FOR PREPARING 16β-METHYL STEROID COMPOUND

Pub. No.:    WO/2018/196883    International Application No.:    PCT/CN2018/092329
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Jun 23 01:59:59 CEST 2018
IPC: C07J 1/00
Applicants: GUANGXI WONDER PHARMACEUTICAL CO. LTD
广西万德药业有限公司
Inventors: YANG, Kun
杨坤
JIANG, Qingfeng
蒋青锋
YU, Chuanyun
于传云
HUANG, Ruilu
黄瑞禄
Title: METHOD FOR PREPARING 16β-METHYL STEROID COMPOUND
Abstract:
Disclosed is a method for preparing 16β-methyl steroid compound, comprising a methylenation reaction and a hydrogenation reduction reaction. Compared to the prior art, the preparation method of the present invention orientedly synthesizes 16β-methyl while avoiding the side reaction which forms 16α-methyl and 15 (16)-alkene, and produces a highly pure product having a HPLC greater than or equal to 96%. Furthermore, the raw excipient used in the present invention is cheap and accessible, the synthesis process is short, and each reaction step is easily implementable with high yield, thereby enabling more economical and safer production.