Search International and National Patent Collections
|1. (WO2018196883) METHOD FOR PREPARING 16β-METHYL STEROID COMPOUND|
|Applicants:||GUANGXI WONDER PHARMACEUTICAL CO. LTD
|Title:||METHOD FOR PREPARING 16β-METHYL STEROID COMPOUND|
Disclosed is a method for preparing 16β-methyl steroid compound, comprising a methylenation reaction and a hydrogenation reduction reaction. Compared to the prior art, the preparation method of the present invention orientedly synthesizes 16β-methyl while avoiding the side reaction which forms 16α-methyl and 15 (16)-alkene, and produces a highly pure product having a HPLC greater than or equal to 96%. Furthermore, the raw excipient used in the present invention is cheap and accessible, the synthesis process is short, and each reaction step is easily implementable with high yield, thereby enabling more economical and safer production.