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1. (WO2018196870) DRUG TARGETING PROSTAGLANDIN E2 AND RECEPTOR THEREOF AND APPLICATION

Pub. No.:    WO/2018/196870    International Application No.:    PCT/CN2018/085035
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sun Apr 29 01:59:59 CEST 2018
IPC: A61K 31/557
A61K 9/00
A61K 47/00
A61K 48/00
Applicants: FUWAI HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES
中国医学科学院阜外医院
Inventors: WANG, Miao
王淼
HAO, Huifeng
郝会峰
HU, Sheng
胡昇
Title: DRUG TARGETING PROSTAGLANDIN E2 AND RECEPTOR THEREOF AND APPLICATION
Abstract:
The present invention provides a method for regulating vascular remodeling in a subject, comprising administering an effective amount of a substance capable of upregulating signaling activities of PGE2 receptors EP4 and/or EP2 signaling pathways to the subject. The present invention also provides an application of the substance capable of upregulating signaling activities of PGE2 receptors EP4 and/or EP2 signaling pathways in preparing a drug for regulating vascular remodeling in a subject. The present invention also provides a preparation for regulating vascular remodeling in a subject, comprising the substance capable of upregulating signaling activities of PGE2 receptors EP4 and/or EP2 signaling pathways.