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1. (WO2018196861) GUANIDINE DERIVATIVE
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Pub. No.: WO/2018/196861 International Application No.: PCT/CN2018/084923
Publication Date: 01.11.2018 International Filing Date: 27.04.2018
IPC:
C07D 271/08 (2006.01) ,A61K 31/4245 (2006.01) ,A61P 25/28 (2006.01) ,A61P 27/02 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
271
Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02
not condensed with other rings
08
1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
鲁南制药集团股份有限公司 LUNAN PHARMACEUTICAL GROUP CORPORATION [CN/CN]; 中国山东省临沂市 红旗路209号 No. 209, Hongqi Road Linyi, Shandong 276005, CN
Inventors:
张贵民 ZHANG, Guimin; CN
姚景春 YAO, Jingchun; CN
任玉珊 REN, Yushan; CN
Agent:
中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE; 中国北京市 西城区阜成门外大街2号万通新世界广场8层 8th Floor, Vantone New World Plaza, 2 Fuchengmenwai Street, Xicheng District Beijing 100037, CN
Priority Data:
201710288663.127.04.2017CN
Title (EN) GUANIDINE DERIVATIVE
(FR) DÉRIVÉ DE GUANIDINE
(ZH) 亚氨脲衍生物
Abstract:
(EN) The present invention relates to the field of pharmaceuticals, and in particular to a guanidine derivative containing a furan structure and a composition thereof. The derivative and the composition thereof can be used for preparing pharmaceuticals for treating pathological feature diseases having indoleamine 2,3-dioxygenase mediated tryptophan metabolic pathways. The present invention further relates to a method for preparing the derivative and a midbody thereof.
(FR) La présente invention se rapporte au domaine des produits pharmaceutiques, et concerne en particulier un dérivé de guanidine contenant une structure furannique et une composition de celui-ci. Le dérivé et la composition correspondante peuvent être utilisés pour préparer des produits pharmaceutiques pour le traitement de maladies à caractères pathologiques ayant des voies métaboliques de tryptophane à médiation par l'indoléamine 2,3-dioxygénase. La présente invention concerne en outre un procédé de préparation du dérivé et d'un corps intermédiaire de celui-ci.
(ZH) 本发明涉及药物领域,特别涉及含有呋喃结构的亚氨脲衍生物及其组合物,该衍生物及其组合物可用于制备治疗具有吲哚胺2,3-双加氧酶介导的色氨酸代谢途径的病理学特征疾病的药物。本发明还涉及用于制备该衍生物及其中间体的方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)