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1. (WO2018196819) PROTEIN PARTICLE WRAPPED WITH MEDICINE INSOLUBLE IN WATER AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2018/196819    International Application No.:    PCT/CN2018/084654
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 27 01:59:59 CEST 2018
IPC: A61K 47/64
A61K 9/14
A61K 31/337
A61K 31/4745
A61K 31/436
A61K 31/496
Applicants: ACADEMY OF MILITARY MEDICAL SCIENCES
中国人民解放军军事科学院军事医学研究院
Inventors: LI, Zhiping
李志平
YANG, Zhenbo
杨臻博
YANG, Yang
杨阳
YU, Fanglin
喻芳邻
GONG, Wei
龚伟
YANG, Meiyan
杨美燕
WANG, Yuli
王玉丽
GAO, Chunsheng
高春生
MEI, Xingguo
梅兴国
Title: PROTEIN PARTICLE WRAPPED WITH MEDICINE INSOLUBLE IN WATER AND PREPARATION METHOD THEREFOR
Abstract:
A protein particle wrapped with a medicine insoluble in water and a preparation method therefor. The preparation method comprises the following steps: i) dissolving a medicine insoluble in water and a liquid solubilizer in a good solvent of the medicine insoluble in water; ii) removing part or all of the good solvent of the medicine insoluble in water from products obtained in step i); iii) mixing products obtained in step ii) with proteins; and iv) dispersing products obtained in step iii) in a poor solvent of the medicine insoluble in water. The preparation method is simple and is suitable for industrial production.