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|1. (WO2018196819) PROTEIN PARTICLE WRAPPED WITH MEDICINE INSOLUBLE IN WATER AND PREPARATION METHOD THEREFOR|
|Applicants:||ACADEMY OF MILITARY MEDICAL SCIENCES
|Title:||PROTEIN PARTICLE WRAPPED WITH MEDICINE INSOLUBLE IN WATER AND PREPARATION METHOD THEREFOR|
A protein particle wrapped with a medicine insoluble in water and a preparation method therefor. The preparation method comprises the following steps: i) dissolving a medicine insoluble in water and a liquid solubilizer in a good solvent of the medicine insoluble in water; ii) removing part or all of the good solvent of the medicine insoluble in water from products obtained in step i); iii) mixing products obtained in step ii) with proteins; and iv) dispersing products obtained in step iii) in a poor solvent of the medicine insoluble in water. The preparation method is simple and is suitable for industrial production.